Modeling Evolution
Course Number: 02-331
Some of the most serious public health problems we face today, from drug-resistant bacteria, to cancer, all arise from a fundamental property of living systems -- their ability to evolve. Since Darwin's theory of natural selection was first proposed, we have begun to understand how heritable differences in reproductive success drive the adaptation of living systems. This makes it intuitive and tempting to view evolution from an optimization perspective. However, genetic drift, phenotypic trade-offs, constraints, and changing environments, are among the many factors that may limit the optimizing force of natural selection. This tug-of-war between selection and drift, between the forces that produce variation in a population, and the forces suppressing this variation, make evolutionary processes much more complex to model and understand than previously thought. The aim of this class is to provide an introduction into the theoretical formalism necessary to understand how biological systems are shaped by the forces and constraints driving evolutionary dynamics.
Academic Year: 2026-2027
Semester(s): Spring
Prerequisite(s): (02120 or 15112) and (21241) and (21325 or 36218 or 15259 or 36225)
Location(s): Pittsburgh