糖心Vlog视频

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Biological Pathways

In addition to measures related to the assessment of infection and colds, the 5 studies included numerous other biological measurements that were taken at baseline (i.e, pre-viral challenge).  While not all measures were included in each study, many variables were assessed in two or more.  Examples of such assessments include screening measures used to verify study eligibility (e.g., complete blood cell counts, HIV seropositivity), anthropometric measures, and assessments of basal cardiovascular and endocrine activity.  The table below lists all of the baseline biological measures that were collected across the 5 studies and identifies which studies included each measure.  More detailed information on how each biological variable was assessed can be obtained by clicking on the name of the specific measure.

Category Measure BCS  PCS1 PCS2 PMBC PCS3
Anthropometry Height, weight, waist circumference, etc. ✔ ✔ ✔ ✔ ✔
Biological Aging Lymphocyte telomere length* ✔
ENT Measures
     Nasal exam Gross mucosal pathology, physician report ✔ ✔ ✔ ✔ ✔
     Ear exam
Middle ear pressure ✔ ✔ ✔ ✔
Genotyping Polymorphisms relevant to inflammation and sympathetic & HPA response      ✔
Handedness Study questionnaire ✔
Immunity
     Functional Glucocorticoid resistance*     ✔  ✔
     Functional Latent virus infection* ✔
     Functional Natural killer (NK) cell cytotoxicity ✔   
     Functional Local (nasal) cytokine response to challenge ✔ ✔ ✔ ✔
     Functional Local (nasal) bradykinin response to challenge ✔
     Functional Stimulated cytokine production   ✔
     Quantitative Lymphocyte subsets ✔ ✔
Resting Biological Activity
     Cardiovascular Blood pressure and heart rate (baseline and post-challenge) ✔ ✔  ✔ ✔ ✔
     Cardiovascular Heart rate variability ✔
     Endocrine Catecholamines, 24-hour urine ✔ ✔ ✔
     Endocrine Cortisol, 24-hour urine ✔
     Endocrine Cortisol, hair* ✔
     Endocrine Cortisol, plasma ✔
     Endocrine Cortisol, salivary ✔ ✔ ✔
     Endocrine Creatinine, 24-hour urine ✔ ✔ ✔
     Metabolic Body temperature (baseline & post-challenge) ✔ ✔ ✔ ✔ ✔
     Metabolic Total cholesterol ✔ ✔
     Oxidative Stress F2-isoprostanes, urine ✔
Screening
Antibody to challenge virus ✔ ✔
Blood chemistry ✔ ✔ ✔ ✔ ✔
CBC w/platelets & differential ✔ ✔ ✔ ✔
HIV antibody ✔ ✔ ✔ ✔
Pregnancy test ✔ ✔ ✔ ✔ ✔
Screen for pre-challenge infection with nonspecific respiratory viruses ✔ ✔ ✔ ✔
Urinalysis ✔ ✔ ✔ ✔ ✔
Viral-specific neutralizing serum Ab ✔ ✔ ✔ ✔ ✔
Stress Reactivity
     Cardiovascular Blood pressure ✔
     Cardiovascular Heart rate ✔
     Cardiovascular Heart rate variability ✔
     Endocrine Cortisol, salivary ✔
* Measured in a subsample of participants